Because neither Labrax nor Plesidippus can be found, Trachalio comes to the conclusion that his master has been cheated by the pimp, who was actually shipwrecked and so was not able to meet Plesidippus; Trachalio states that he had predicted this, and comically proclaims that he is a soothsayer.It is a comedy, which describes how a girl, Palaestra, stolen from her parents by pirates, is reunited with her father, Daemones, ironically, by means of her pimp, Labrax.
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After recruitment and activation of the intra-cellular kinases, downstream pathways are initiated.Genetic polymorphisms and mutations affecting these signaling pathways are associated with increased numbers of autoreactive B cells ( Table 1 ).Table 1. Some Genetic Abnormalities Causing Increased Numbers of Autoreactive B Cells Gene Defect Checkpoint(s) Mechanism PTPN22 C1858T Central and peripheral Reduced deletionediting in BM; regulation of memory B cells a MyD88, IRAK4, or UNC93B1 Mutation Central Abnormal regulation of TLR signaling resulting in increased numbers of polyreactive immature B cells without autoantibody production b Btk Transgene expression in mice Central and peripheral Alters threshold for B cell activation and negative selection of autoreactive B cells c Lyn B-cell deficiency Peripheral Abnormal GC formation, increased BAFF, activation of transitional and follicular B cells with autoantibodies d Fcgr2b Deficiency in mice (knockout) Peripheral Increased numbers of autoreactive GC B cells e Tnfsf13b (BAFF) Transgene expression in mice Peripheral Hyperactive NFB2 signaling, expanded MZ B cells, increased GC formation f AICDA (aid) Deficiency (mutation) Central Abnormal Ig repertoire and increased serum autoantibodies (due to decreased SHM away from autoreactivity) g a Rhee I, et al.The immature BCR repertoire contains many that bind DNA or other self-antigens.
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